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FDA reports 51 deaths of attention drug patients
By ABC News

WASHINGTON - Deaths of 51 U.S. patients who took widely prescribed drugs to treat attention deficit disorder prompted regulators to start watching for heart attacks, high blood pressure and other problems in 2004, a report released on Wednesday said.

The U.S. Food and Drug Administration staff did not say the drugs were responsible for the fatalities, but they urged close monitoring for "the rare occurrence of pediatric sudden death during stimulant therapy."

"These reports themselves do not establish a causal relationship between these medications and cardiovascular adverse events," wrote Dr. Gerald Dal Pan, director of the FDA's Office of Drug Safety, in a separate notice on the agency Web site.

The information was released one day ahead of an FDA advisory panel meeting on how best to study potential risks from the drugs, which include Shire Pharmaceuticals Group Plc's Adderall and Novartis AG's Ritalin.

FDA staff scientists and experts will provide updated information at the meeting about serious health problems that have been reported, the agency said.

Use of drugs to treat attention deficit hyperactivity disorder, or ADHD, was controversial before the cardiac issue emerged, with many doctors and parents arguing the medicines are overprescribed.

The FDA said it decided to seek input from an advisory panel after reports of sudden death, high blood pressure, heart attacks and strokes among some of the millions of adults and children who have taken the medicines.

Through 2003, 24 deaths were reported from 1999 through 2003 among U.S. patients who took Adderall for ADHD, the FDA staff report said. The agency excluded cases that appeared linked to intoxication from multiple drugs or other causes.

Another 16 deaths were reported through 2003 in U.S. patients who took Ritalin or other ADHD drugs known as methylphenidates, the report said. Eleven deaths were reported among other drugs besides Adderall in the amphetamine class, it said.

"Conclusions about the relative safety of these two stimulant therapies cannot be made on the basis of this analysis," the FDA staff said.

Thirty additional deaths of methylphenidate patients were recorded but they were either non-U.S. cases or occurred outside the review period, the report said.

Shire spokesman Matthew Cabrey said data have not shown any correlation between Adderall and the sudden deaths reported among children. He said the company supports the FDA's review of the matter.

Health Canada temporarily suspended Adderall sales last year after 20 reports of sudden death in people who took it. The agency allowed Adderall back on the market after concluding it could not prove the drug was more risky than other therapies.

Novartis said its own review found no increased risk of cardiovascular problems in patients who took methylphenidates compared with the general population.

The FDA also has been studying if ADHD drugs may be related to psychiatric problems.

Republican Sen. Charles Grassley charged the FDA had taken a "disjointed" approach to the drugs over the past year. In a letter to the agency, the Iowa Republican suggested a "comprehensive" review of all ADHD medicines.

Shares of British firm Shire fell 3.2 percent to 890.2 pence in London trading. Novartis shares gained 5 cents to close at $54.70 on the New York Stock Exchange.

Copyright 2006 Reuters News Service. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


Reuters Source: http://abcnews.go.com/US/print?id=1595545

 

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Attention deficit hyperactivity disorder 101
Introduction This is a type of mental disorder, which occurs primarily in school-aged children but can also be diagnosed for the first time in the late teens esp., if some of its symptoms are left unnoticed. It was once falsely thought that after...6 Tips for ADHD Self Awareness and Everybody Else Too
People with ADHD, (Attention Deficit / Hyperactivity Disorder) are often unaware of how others see them. They may appear angry when they are only struggling to do a menu for tonight's dinner, or they seem to be laughing when the boss is chewing on...

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